产品货号：
Z20603
中文名称：
MRE11抗体
英文名称：
Anti-MRE11 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MRE11 Antibody |
| 指标别名 | ATLD;HNGS1;MRE11;MRE11 homolog 1;MRE11 homolog A;MRE11A;MRE11B |
| 克隆性 | Polyclonal |
| 检验物种 | mouse |
| 应用范围 | ELISA,WB |
| 基因名称 | MRE11A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 68-706 of mouse Mre11 protein. |
| 计算分子量 | 81kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against mouse Mre11 protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.?A BLAST analysis was used to suggest cross-reactivity with Mre11 protein from rat (94% homology).Based on protein sequence homology also expect partial reactivity against Mre11 homologues from macaque (88%),human (84%) and dog (82%).This sequence shows less than 75% homology to homologues from bovine,Xenopus,chicken,chimpanzee and zebrafish sources.Reactivity against homologues from other sources is not known. |
| 浓度 | 1.05mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Mre11 is a component of the MRN complex (Mre11/Rad50/Nbs1),which plays a central role in double-strand break (DSB) repair,DNA recombination,maintenance of telomere integrity and meiosis.The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity,which are provided by MRE11A.RAD50 may be required to bind DNA ends and hold them close.This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates,and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point.The complex may also be required for DNA damage signaling via activation of the ATM kinase.In telomeres,the MRN complex may modulate t-loop formulation.Anti-Mre11 Antibody is useful for researcher interested in DNA Damage and Repair and Nuclear Signaling Research. |
| Uniprot ID | Q61216 |
| 基因名全称 | Double-strand break repair protein MRE11A |
| 推荐稀释比 | ELISA:1:10,000 - 1:50,000 WB:1:500 - 1:2,000 |
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